Toll-like receptor-mediated IRE1a activation as a therapeutic target for inflammatory arthritis

Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang* and Deyu Fang* Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA, Department of Surgery, Jimo Hospital of Chinese Traditional Medicine, Qingdao, China, Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, Heilongjiang Provincial Key Laboratory of Neurobiology, Department of Neurobiology, Harbin Medical University, Harbin, China, Department of Clinical Biochemistry, Third Military Medical University, Chongqing, PR China, Neuroscience, Aging, and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA, Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA